SidaGhanaV1, Main, Exploration, bibRecord, 001242

Molecular Epidemiology of HTLV-II among United States Blood Donors and Intravenous Drug Users: An Age–Cohort Effect for HTLV-II RFLP Type a0

Identifieur interne : 001242 ( Main/Exploration ); précédent : 001241; suivant : 001243

Molecular Epidemiology of HTLV-II among United States Blood Donors and Intravenous Drug Users: An Age–Cohort Effect for HTLV-II RFLP Type a0

Auteurs : Edward L. Murphy ; Renaud Mahieux [France] ; Guy De Thé [France] ; Fredj Tekaia [France] ; Dannie Ameti [États-Unis] ; Jacqueline Horton [États-Unis] ; Antoine Gessain [France]

Source :

Virology [ 0042-6822 ] ; 1998.

RBID : ISTEX:6E7673E1DA630ABB7B43F1C7FD81517561532FDB

Descripteurs français

Wicri :
- topic : épidémiologie.

English descriptors

Abstract

Molecular subtyping was used to investigate the epidemiology of human T-lymphotropic virus type II (HTLV-II) in the United States. Nested polymerase chain reaction of the HTLV-II long terminal repeat region followed by restriction fragment length polymorphism (RFLP) analysis was performed on HTLV-II seropositive subjects including 97 U.S. blood donors without major risk factors for HTLV-II infection, 53 injection drug users (IDU), and 10 American Indian blood donors. Three new HTLV-II RFLP types were confirmed with DNA sequencing and phylogenetic analysis. HTLV-II RFLP type a0 (Switzer classification) was associated with older age [adjusted odds ratio (OR) 1.06 per year of age, 95% confidence interval (CI) 1.02–1.09] and with Black (OR 5.24, 95% CI 1.90–14.47) and White (OR 4.43, 95% CI 1.67–11.75) race/ ethnicity. These data are consistent with an age–cohort effect for HTLV-II RFLP type a0 among older White and Black IDU and blood donors. This finding could be explained by an epidemic of non-a0 HTLV-II RFLP types among younger persons of Hispanic and other race/ethnicity, superimposed upon endemic HTLV-II RFLP type a0 among older Black and White persons.

Url:

https://api.istex.fr/document/6E7673E1DA630ABB7B43F1C7FD81517561532FDB/fulltext/pdf

DOI: 10.1006/viro.1997.9009

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Molecular subtyping was used to investigate the epidemiology of human T-lymphotropic virus type II (HTLV-II) in the United States. Nested polymerase chain reaction of the HTLV-II long terminal repeat region followed by restriction fragment length polymorphism (RFLP) analysis was performed on HTLV-II seropositive subjects including 97 U.S. blood donors without major risk factors for HTLV-II infection, 53 injection drug users (IDU), and 10 American Indian blood donors. Three new HTLV-II RFLP types were confirmed with DNA sequencing and phylogenetic analysis. HTLV-II RFLP type a0 (Switzer classification) was associated with older age [adjusted odds ratio (OR) 1.06 per year of age, 95% confidence interval (CI) 1.02–1.09] and with Black (OR 5.24, 95% CI 1.90–14.47) and White (OR 4.43, 95% CI 1.67–11.75) race/ ethnicity. These data are consistent with an age–cohort effect for HTLV-II RFLP type a0 among older White and Black IDU and blood donors. This finding could be explained by an epidemic of non-a0 HTLV-II RFLP types among younger persons of Hispanic and other race/ethnicity, superimposed upon endemic HTLV-II RFLP type a0 among older Black and White persons.</div>
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Molecular Epidemiology of HTLV-II among United States Blood Donors and Intravenous Drug Users: An Age–Cohort Effect for HTLV-II RFLP Type a0

Molecular Epidemiology of HTLV-II among United States Blood Donors and Intravenous Drug Users: An Age–Cohort Effect for HTLV-II RFLP Type a0

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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